Triple marker test is an investigative blood test carried out at the end of first trimester of pregnancy. The test helps in detecting the risk level of any chromosomal disabilities or genetic defects in the fetus. The test measures the level of three important substances of the placenta namely, alpha-fetoprotein (AFP), human chorionic gonadotropin (hCG) and estriol, and is hence known as triple marker test. It is also known as triple screen test, multiple marker or AFP marker test.
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|Ahmedabad||Rs. 2218.00||Rs. 1600.00||Rs. 3000.00|
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|Bangalore||Rs. 2704.00||Rs. 1300.00||Rs. 4200.00|
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Triple marker test is a simple blood test done in clinics, hospitals and diagnostic centres. The result of this test is usually presented as probability in the form of a ratio to assess the risk of any chromosomal disorder in the fetus. The marker test is highly advised for pregnant women who have a family history of genetic defects, are suffering from diabetes, obesity, and are above 35 years of age. The results obtained should be discussed thoroughly with the gynaecologist.
Estriol is a weak estrogen that is synthesized by the placenta during pregnancy. It can be measured in the mother's blood as well as urine to determine the health of the fetus and to screen for any anomalies. Low levels of estriol in pregnant women indicates the possibility of the chromosomal defects like Down's syndrome or Edward's syndrome. The result is more potent when combined with high HCG and low AFP levels.
Human chorionic gondatotropin (hCG) is a hormone produced by placenta and decrease in the levels of this hormone indicates problems in pregnancy, like miscarriage. High levels of HCG may indicate a molar pregnancy or a multiple pregnancy.
Alpha-fetoprotein (AFP) is produced by the fetus and is usually measured to screen for abnormalities in the fetus. If AFP levels are significantly elevated, doctors check for neuronal tube defects. If AFP levels are low, with a high hCG, it may indicate Down's Syndrome. Down's syndrome is a chromosomal disorder of the 21st chromosome. It leads to slow growth and development of the baby. The test results are given in a form of a risk ratio. If the risk ratio is on the higher side, amniocentesis test is advised.
Triple marker test is often carried out between 14th-18th week of pregnancy. It is a simple procedure where a sample of blood is collected from the arm of the pregnant woman and the sample is sent to lab for further analysis. Precautions like informing the doctor about medicines or medical conditions or allergies is important. There are no risks associated with the test since it is a fairly simple procedure. The mother's ethnicity, weight, age, and gestation period are combined with the results to assess the possibility of genetic disorders.
It is very important to discuss the test results with the doctor since this test has high incidences of false positives. Doctors will interpret the results and suggest the further steps accordingly.